Vasularized and cancellous autograft shows optimal skeletal incorporation but is limited by morbidity concerns (3).
Using the MARROW CELLUTION™ Bone Core Device, the clinician can create a combination graft of a vascularized intact bone core in the center of the graft surrounded by allogeneic, autologous or synthetic bone chips hydrated with cellular marrow aspirate.
Higher quality, less quantity, delivered appropriately minimizes host morbidity.
Intact Bone Cores vs. Morselized Bone.
Harvesting intact cancellous bone cores without disrupting the highly-organized living tissue is superior to transplanting pieces of bone. Intact grafts maintain the micro-vascular network within the graft, promoting bone callus formation/remodeling and do not exhibit extensive resorption. (1,2)
Intact bone exploits the biology of normal fracture healing rather than through slow creeping substitution associated with the slow incorporation of a non-vascularized graft. (1)
Research demonstrates the enhanced surivival of a bone graft as long as its primary blood supply is preserved. A living bone graft will shorten the time for bony onion because the reconstructed bone is comparable to a bone with a double fracture. (1,2)
Allogeneic or synthetic bone chips hydrated with marrow can be packed around the living bone graft/core to accelerate anastomosis into the graft and minimize morbidity. (1,2)
1) Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (Sep 2007). "Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice". Cancer Research. 67 (17): 8149–55.
2) Ostrup et al Distant transfer of a free, living bone graft by micro-vascular anastomoses. An experimental study. Plast Reconstr. Surg. 1974 Sep; 54(3): 274-85
3) Taylor G The Free Vascularized Bone Graft: A Clinical Extension of Microvascular Techniques Plastic & Reconstructive Surgery May 1975 volume 55 Issue 5 ppg 533-544